NOW. ESSENTIAL AMINO ACID: L-Histidine is an that is best kNOWn for its role in the production of histamine, an important mediator of immune system responses* Critical for normal brain function, as well as for the maintenance of a healthy skin barrier* Plays important roles in muscle function, cardiovascular health, protection against free radicals, and the elimination of heavy metals from the body* GMP Quality Assured: NPA A-rated GMP certification means that every aspect of the NOW manufacturing process has been examined, including our laboratory/testing methods (for stability, potency, and product formulation). Packaged in the USA by a family owned and operated company since 1968.