I stumbled upon this wonderful product and so glad I did! I have the C677T MTHFR mutation, as well as a COMT mutation. MTHFR converts B-12 and Folate (and other vitamins) to the active/methylated forms that can be used by the body and cross the blood brain barrier. Because I have both MTHFR and COMT mutations, it is best that I take B12 in the form of Adenosylcobalamin (along with Methylcobalamin), which this product has. I was taking Thorne Methyl Guard Plus, which has a higher potency of Methylfolate and B12 Methylcobalamin (and no Adenosylcobalamin), but noticed it made me a little irritable, edgy. So after watching a presentation by Dr. Ben Lynch (MTHFR.net) – a leader in MTHFR research - I learned that B12 Adenosylcobalamin can help reduce irritability, anger, etc. that those with COMT mutations can have when they take too much methylfolate. This supplement has helped “take the edge off” (pun intended). <br /><br />This particular supplement formulation seems to work for me, my son and my father. I have noticed increased energy and mood stability and less irritability in all of us. And, as for my 90-year-old father, he was on antidepressants for 10 years (as well as on and off of them for the prior 55 years). 2014 blood work showed B12 deficiency, so he started B12 (cyanocobalamin) shots, but saw no improvement, and his antidepressants were gradually increased. In October 2015, his blood work showed he was in range for B12 and folate, but his homocysteine level was high. Because of the research I had done on MTHFR, I knew right away that my dad had an MTHFR mutation, because (1) when blood homocysteine is elevated while B12 and Folate are in the normal range, that indicates the body is not properly converting folic acid to methylated folate and B12 (cyanocobalamin-synthetic form) to methylated B12 (active forms used by the body); (2) I had to get my MTHFR mutation from a parent. The form of B12 in the shots my dad was taking monthly is cyanocobalamin, which is synthetic and cheap and requires properly working MTHFR for conversion. So keep in mind that B12 and folate levels in blood work alone is not an accurate indicator of whether or not the body is actually converting to active forms required for the body to utilize. The addition of a homocysteine test is more revealing. Since my dad started taking Thorne B Complex #12, he is completely off of antidepressants and doing well! His doctors are intrigued and impressed. I gave them the information and hope they will use it to help other patients. Every person is different. It is best to start with lower potency supplements and work your way up to prevent reactions (in my case, reaction to too much methylfolate).<br /><br />Dr. Ben Lynch has two MTHFR mutations himself, so he has a personal interest in this field. MTHFR.net is a FABULOUS resource for those struggling with MTHFR mutations, or those who want to find out if they have such mutations. It is now believed that at least 50% of the population has some MTHFR variant (SNPs), which can cause a host of problems, including fibromyalgia, miscarriages, severe depression, autism and much more. While there is typically not one “smoking gun” that causes all our ailments, I believe MTHFR is a good place to start. MTHFR.net can tell you which tests to have and where to get them. I hope this helps someone!

This is an excellent product. Thorne lists it as hypoallergenic and it contains no preservatives, magnesium stearate, or any "flowing agents". It contains biologically active forms of vitamin B12, plus two active forms of folate. According to my doctor some people's systems have trouble synthesizing B12 and folate, so this product is a good choice for them because the active forms are readily available. B vitamins are important for brain health ([...]) and taking this product seems to improve my energy levels and mood. If you think you need to take a b vitamin complex, you should consider this product.

Update 7/22/16: I've been taking one capsule daily for nearly 2 months now. My energy level has increased dramatically and i feel better overall. While my energy levels aren't what they were before RA and hypothyroidism, I'm fairly certain nothing would do that. Still, i feel like I've been cut loose from a 200lb anchor I've been dragging around. Seriously, it's pretty great! And I do tire out, but i don't feel like I'm on empty before I get started.<br /><br />I've been taking b vitamin supplements for over a decade now. I first began on recommendation of a doctor, that many women don't get enough b vitamins. I bought whatever b-complex was on sale.<br /><br />In the past 6 years, i've had a number of chronic health problems crop up, including GI dysfunction and the autoimmune disease rheumatoid arthritis. I have become intolerant to dairy and gluten, and due to gastroparesis and not having a gallbladder, I cannot digest meat. Eating a gluten-free and vegan diet has helped my GI issues substantially. However, b-vitamins are hard to come by.<br /><br />Due to my illnesses, I battle extreme fatigue daily. It's probably the hardest part of dealing with chronic illness as a young adult. While i'm doing all I can for my RA and hypothyroidism, I wanted to be sure that I was taking the best b supplement for my body.<br /><br />It's been several years since I've bought vitamins or supplements at a drugstore. I've used Dr's Best and most recently, Jarrow. Both are high quality b-vitamin supplements - I felt a difference in energy level when taking them. However, this Thorne's b-supplement blows them away! I love that there are no fillers, especially magnesium sterate.<br /><br />I really love that there are different b-complexes, depending on your needs. All contain the most active and absorbable forms of b-vitamins and folate in veggie caps with no fillers. Yes, you will pay more for Throne Research products, but you are paying for quality and purity.

I have migraine disease and typically get 1-2 attacks per month. I've read several migraineur studies for B2, B6, and B12 that showed promise, so I decided to try supplementing. It was difficult to find something with good, absorbable forms of these vitamins, and I was very pleased to find no cyanocobalamin in this formula. There are no ridiculously high levels of any of the nutrients either. I do not know if I have the MTHFR gene variant but figured something with the methylated forms should be good.<br /><br />Within a month or two of taking a single one of these daily, my migraine attacks no longer have nausea and vomiting, and even my sensitivity to light and sound during an attack isn't as bad as it used to be. I still have the same amount of attacks, but not having nausea makes it easier to take abortive medication to deal with the pain, and not having the intolerable reaction to light and sound has reduced the overall level of misery. It has been so helpful to have the other symptoms taken away, and is the single most impactful thing I've tried to reduce the burden of the attacks. It has not helped my post-drome phase at all, and I'm not really sure it has reduced the pain levels; nevertheless, it's a cheap and extremely valuable pill.

I decided to try these out to see if they would help with some nerve pain I was having. While they haven’t really helped that issue I did notice a huge spike in energy when taking them. After taking the whole bottle I ran out for a couple of weeks and during that time I went back to feeling very sluggish and low energy. Within an hour after taking my pill each morning I feel like I’ve had a cup of coffee and I’m good to go the rest of the day. These have been great!

These were prescribed for me by my doctor from this specific company. I am allergic to just about everything and that includes every vitamin supplement I have tried (not the vitamins but what is added to the formulation or the source of the vitamin). I have problems with vitamin absorption from food and have taken these for about 4 months. I am feeling much better and have had no allergic reactions to them yet. They are supposed to be one of the best on the market and very pure. Amazon as usual has excellent pricing and shipments are received very fast and undamaged.